The effects of tramadol on hepatic ischemia/reperfusion injury in rats | Zendy

Mona F. Mahmoud | Zendy; Samar Gamal | Zendy; Mohamed A. Shaheen | Zendy; HassanM El-Fayoumi | Zendy

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The effects of tramadol on hepatic ischemia/reperfusion injury in rats

Author(s) -

Mona F. Mahmoud,

Samar Gamal,

Mohamed A. Shaheen,

HassanM El-Fayoumi

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.182882

Subject(s) - tramadol , oxidative stress , reperfusion injury , pharmacology , medicine , tumor necrosis factor alpha , superoxide dismutase , ischemia , apoptosis , analgesic , cytokine , antioxidant , anesthesia , chemistry , endocrinology , biochemistry

Tramadol is a centrally acting synthetic analgesic. It has a cardioprotective effect against myocardial ischemia-reperfusion (I/R) injury in isolated rat heart. We hypothesized that tramadol may exert a similar protective effect on hepatic I/R injury. Hence, the current investigation was designed to study the possible protective effects of tramadol on experimentally-induced hepatic I/R injury in rats.

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