Open AccessThe effects of tramadol on hepatic ischemia/reperfusion injury in rats
Author(s) -
Mona F. Mahmoud,
Samar Gamal,
Mohamed A. Shaheen,
Hassan M. ElFayoumi
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.182882
Subject(s) - tramadol , oxidative stress , reperfusion injury , pharmacology , medicine , tumor necrosis factor alpha , superoxide dismutase , ischemia , apoptosis , analgesic , cytokine , antioxidant , anesthesia , chemistry , endocrinology , biochemistry
Tramadol is a centrally acting synthetic analgesic. It has a cardioprotective effect against myocardial ischemia-reperfusion (I/R) injury in isolated rat heart. We hypothesized that tramadol may exert a similar protective effect on hepatic I/R injury. Hence, the current investigation was designed to study the possible protective effects of tramadol on experimentally-induced hepatic I/R injury in rats.