Open AccessEffect of drugs modulating serotonergic system on the analgesic action of paracetamol in mice
Author(s) -
Yogita Surendra Karandikar,
Peeyush Belsare,
Aditi Panditrao
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.182874
Subject(s) - analgesic , ondansetron , buspirone , fluoxetine , pharmacology , tramadol , serotonergic , serotonin , medicine , serotonin reuptake inhibitor , agonist , anesthesia , vomiting , receptor
The underlying mechanisms for the analgesic action of paracetamol (PCT) are still under considerable debate. It has been recently proposed that PCT may act by modulating the Serotonin system. This study was conducted to verify the influence of Serotonin modulating drugs (buspirone, ondansetron, and fluoxetine) on the analgesic effect of PCT.