The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice | Zendy

Karolina Pytka | Zendy; Elżbieta Żmudzka | Zendy; Klaudia Lustyk | Zendy; Anna Rapacz | Zendy; Adrian Olczyk | Zendy; Adam Gałuszka | Zendy; Anna M. Waszkielewicz | Zendy; Henryk Marona | Zendy; Jacek Sapa | Zendy; Barbara Filipek | Zendy

Open Access

The antidepressant- and anxiolytic-like activities of new xanthone derivative with piperazine moiety in behavioral tests in mice

Author(s) -

Karolina Pytka,

Elżbieta Żmudzka,

Klaudia Lustyk,

Anna Rapacz,

Adrian Olczyk,

Adam Gałuszka,

Anna M. Waszkielewicz,

Henryk Marona,

Jacek Sapa,

Barbara Filipek

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.182872

Subject(s) - anxiolytic , piperazine , xanthone , moiety , antidepressant , pharmacology , derivative (finance) , chemistry , medicine , stereochemistry , anxiety , psychiatry , business , finance

Xanthones are flavonoids with numerous activities, including antioxidant, antidepressant., or anxiolytic-like. Therefore, the aim of our study was to determine antidepressant- and anxiolytic-like properties of four xanthone derivatives (3-chloro-5-[(4-methylpiperazin-1-yl)methyl]-9H-xanthen-9-one dihydrochloride [HBK-5], 6-methoxy-2-[(4-methylpiperazin-1-yl) methyl]-9H-xanthen-9-one dihydrochloride, 2-[(4-benzylpiperazin-1-yl) methyl]-6-methoxy-9H-xanthen-9-one dihydrochloride, 2-{[4-(2-methoxyphenyl) piperazin-1-yl] methyl}-9H-xanthen-9-one hydrochloride), as well as the influence on cognitive and motor function of active compounds, using animal models.

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