Open AccessPure red cell aplasia due to azathioprine therapy for Crohn′s disease
Author(s) -
Nagesh Kamat,
C. Ganesh Pai,
Thylbert Deltombe
Publication year - 2016
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.174569
Subject(s) - azathioprine , pure red cell aplasia , medicine , discontinuation , disease , crohn's disease , adverse effect , inflammatory bowel disease , anemia , pathological , drug , thiopurine methyltransferase , gastroenterology , intensive care medicine , pharmacology
Various mechanisms contribute to anemia in inflammatory bowel diseases (IBD), drug-related causes being less frequent. The hematological and other adverse events of azathioprine (AZA) therapy are well documented, but drug-associated pure red cell aplasia (PRCA) is an uncommon event. We hereby describe two cases of AZA-associated PRCA in patients with Crohn's disease. The diagnosis was supported by pathological reports, and prompt hematological recovery was seen with discontinuation of the offending drug. This report highlights the need to consider this rare entity in IBD patients in appropriate settings and for adopting adequate precautionary measures.