Morphine blocks the Mesobuthus tamulus venom-induced augmentation of phenyldiguanide reflex and pulmonary edema in anesthetized rats | Zendy

ShripadB Deshpande | Zendy; Aparna Akella | Zendy; AnilK Tiwari | Zendy; OmP Rai | Zendy

Open Access

Morphine blocks the Mesobuthus tamulus venom-induced augmentation of phenyldiguanide reflex and pulmonary edema in anesthetized rats

Author(s) -

ShripadB Deshpande,

Aparna Akella,

AnilK Tiwari,

OmP Rai

Publication year - 2016

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.174560

Subject(s) - pulmonary edema , medicine , anesthesia , morphine , edema , reflex , bolus (digestion) , venom , pharmacology , lung , chemistry , biochemistry

Pulmonary edema, a manifestation of scorpion envenomation syndrome, is attributed to cardiogenic or noncardiogenic factors. Morphine is a drug used for cardiogenic pulmonary edema and its effect on Mesobuthus tamulus (MBT) venom-induced changes is not known. Therefore, we hypothesized that morphine blocks the MBT venom-induced augmentation of phenyldiguanide (PDG) reflex and pulmonary edema.

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