Open AccessInteraction potential of Trigonella foenum graceum through cytochrome P450 mediated inhibition
Author(s) -
Sk Milan Ahmmed,
Pulok K. Mukherjee,
Shiv Bahadur,
Amit Kar,
Kakali Mukherjee,
Sanmoy Karmakar,
Arun Bandyopadhyay
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.165179
Subject(s) - isozyme , trigonella , cyp3a4 , cytochrome p450 , chemistry , microsome , pharmacology , quinidine , ketoconazole , biochemistry , enzyme , traditional medicine , biology , medicine , antifungal , microbiology and biotechnology
The seeds of Trigonella foenum-graecum (TFG) (family: Leguminosae) are widely consumed both as a spice in food and Traditional Medicine in India. The present study was undertaken to evaluate the inhibitory effect of standardized extract of TFG and its major constituent trigonelline (TG) on rat liver microsome (RLM) and cytochrome P450 (CYP450) drug metabolizing isozymes (CYP3A4 and CYP2D6), which may indicate the possibility of a probable unwanted interaction.