Open AccessDual inhibition of acetylcholinesterase and butyrylcholinesterase enzymes by allicin
Author(s) -
Suresh Kumar
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.161274
Subject(s) - allicin , acetylcholinesterase , butyrylcholinesterase , cholinesterase , aché , enzyme , pharmacology , acetylcholine , donepezil , chemistry , biochemistry , medicine , dementia , disease
The brain of mammals contains two major form of cholinesterase enzymes, acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE). The dual inhibition of these enzymes is considered as a promising strategy for the treatment of neurological disorder such as Alzheimer's disease (AD), senile dementia, ataxia, and myasthenia gravis. The present study was undertaken to explore the anticholinesterase inhibition property of allicin.