Open AccessModulation of muscarinic system with serotonin-norepinephrine reuptake inhibitor antidepressant attenuates depression in mice
Author(s) -
Paramdeep Singh,
Thakur Gurjeet Singh
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.161260
Subject(s) - venlafaxine , tail suspension test , antidepressant , pharmacology , behavioural despair test , citalopram , muscarinic antagonist , muscarinic acetylcholine receptor , reuptake inhibitor , antagonist , monoamine neurotransmitter , venlafaxine hydrochloride , medicine , serotonin , psychology , receptor , hippocampus
Several studies suggest that muscarinic receptor antagonist scopolamine is a rapidly acting antidepressant for the treatment-resistant depression. Therefore, this study was carried out to investigate the possibility of synergistic potential of scopolamine with antidepressants for the treatment of depression without memory impairment in mice.