Open AccessA case of early detection of bisphosphonate-related osteonecrosis of the jaw
Author(s) -
Miyu Mori,
Tetsuro Koide,
Yuriyo Matsui,
T Matsuda
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.157137
Subject(s) - osteonecrosis of the jaw , medicine , bisphosphonate associated osteonecrosis of the jaw , teriparatide , bisphosphonate , mandible (arthropod mouthpart) , magnetic resonance imaging , osteoporosis , radiology , dentistry , pathology , bone mineral , botany , biology , genus
Osteonecrosis of the jaws is an adverse reaction associated with the use of bisphosphonates. Although the diagnosis of bisphosphonate-related osteonecrosis of the jaw (BRONJ) is based on symptomatology, it is often detected late because the patients become symptomatic only after osteonecrosis is well established. We describe a case of early oral BRONJ detected by magnetic resonance imaging (MRI) accidentally. Head MRI revealed low signal of T1-weight images in left mandibula. Patient had been treated with minodronate for osteoporosis during 18 months. Based on the MRI findings and medication history, early stage BRONJ could be considered. Therefore minodronate was switched to teriparatide. Thereafter mandible pares-thesias, odontalgia and exposed bone were not observed. This case suggests that MRI is useful for the early detection of BRONJ.