Open AccessDimethyl sulfoxide inactivates the anticancer effect of cisplatin against human myelogenous leukemia cell lines in in vitro assays
Author(s) -
Rahul Raghavan,
Sanith Cheriyamundath,
Joseph Madassery
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.157132
Subject(s) - cisplatin , cytotoxicity , dimethyl sulfoxide , k562 cells , chemistry , mtt assay , in vitro , chronic myelogenous leukemia , adduct , cell culture , leukemia , absorbance , pharmacology , biochemistry , chromatography , immunology , chemotherapy , medicine , biology , organic chemistry , genetics
To investigate the effect of DMSO on cisplatin induced cytotoxicity (invitro) against K562 (Human mylogenous leukemia) cell line and to study the cisplatin-DMSO adduct formation using UV-spectrophotometer.