Open Accessα-tocopherol supplementation prevents lead acetate and hypoxia-induced hepatic dysfunction
Author(s) -
Kusal K Das,
Jameel G. Jargar,
Sikha Saha,
Saeed M Yendigeri,
Shashi Bala Singh
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.157126
Subject(s) - lead acetate , oxidative stress , hypoxia (environmental) , tocopherol , medicine , endocrinology , chemistry , antioxidant , pharmacology , toxicity , vitamin e , oxygen , biochemistry , organic chemistry
Lead (Pb) is a long-known poison of environment and industrial origin. Its prolonged exposure affects cellular material and alters cellular genetics and produces oxidative damages. In this study, we investigated the exposure of chronic sustained hypoxia or lead acetate alone or in combination with or without supplementation of α-tocopherol on hepatic oxidative and nitrosative stress in rats.