Open AccessProtective effects of amifostine on ischemia-reperfusion injury of rat kidneys
Author(s) -
Ayşe Arduçoğlu Merter,
Burhan Mayır,
Okan Erdoğan,
Taner Çolak
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.153427
Subject(s) - amifostine , ischemia , medicine , malondialdehyde , blood urea nitrogen , creatinine , lipid peroxidation , pharmacology , intraperitoneal injection , reperfusion injury , urology , kidney , necrosis , glutathione , oxidative stress , anesthesia , endocrinology , toxicity , chemistry , biochemistry , enzyme
Amifostine is a drug which can eliminate free oxygen radicals that appear in the body after radiation or chemotherapeutic agent exposure. It is used to decrease the renal toxicity of cisplatin. The aim of this study was to determine the role of amifostine in warm ischemia kidney model for prevention of ischemia/reperfusion injury and also to find out the mechanism for prevention from ischemia/reperfusion injury if such an effect does exist.