Open AccessProtective effect of simvastatin and rosuvastatin on trinitrobenzene sulfonic acid-induced colitis in rats
Author(s) -
Rajesh Maheshwari,
R Balaraman,
Girish Sailor,
Dhanya B. Sen
Publication year - 2015
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.150311
Subject(s) - rosuvastatin , simvastatin , colitis , ulcerative colitis , medicine , pharmacology , inflammation , statin , gastroenterology , disease
Statins have anti-inflammatory effects that are not directly related to their cholesterol lowering activity. This study was carried out to evaluate the effect of simvastatin or rosuvastatin on the extent of colonic mucosal damage and on the inflammatory response in trinitrobenzene sulfonic acid (TNBS)-induced ulcerative colitis.