Open AccessEffects of tanshinone IIA on the transforming growth factor β1/Smad signaling pathway in rat cardiac fibroblasts
Author(s) -
Zhan Chen,
Jinhui Tang,
Daming Zhou,
Zhihui Li
Publication year - 2014
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.144933
Subject(s) - smad , fibronectin , transforming growth factor , microbiology and biotechnology , western blot , signal transduction , myocardial fibrosis , intracellular , messenger rna , medicine , chemistry , endocrinology , cardiac fibrosis , immunocytochemistry , fibrosis , biology , extracellular matrix , biochemistry , gene
This study explores the mechanism of tanshinone IIA (TSN)-mediated inhibition of myocardial fibrosis by investigating the effect of TSN on transforming growth factor β1 (TGFβ1) signal transduction in rat cardiac fibroblasts (CFs).