Open AccessProtective effect of L-arginine on gentamicin-induced nephrotoxicity in rats
Author(s) -
İbrahim Başhan,
Perihan Başhan,
Mehmet Ata Seçilmiş,
Erğin Şingirik
Publication year - 2014
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.144915
Subject(s) - gentamicin , nephrotoxicity , creatinine , chemistry , arginine , blood urea nitrogen , urine , endocrinology , medicine , pharmacology , kidney , biochemistry , antibiotics , amino acid
L-arginine has a protective effect on gentamicin-induced renal failure and it may decrease the tubular reabsorption of another cationic substance, gentamicin due to its cationic structure. The aim of this study is to compare the possible protective effects of L-arginine and its inactive isomer D-arginine on gentamicin-induced nephrotoxicity in rats.