Open AccessNovel 2,5-disubstituted-1,3,4-oxadiazoles as anti-inflammatory drugs
Author(s) -
Ega Durgashivaprasad,
Geetha Mathew,
Sarine Sebastian,
S.A. Manohar Reddy,
Jayesh Mudgal,
Gopalan Kutty Nampurath
Publication year - 2014
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.140584
Subject(s) - in vivo , carrageenan , anti inflammatory , arthritis , pharmacology , inflammation , chemistry , nitric oxide , myeloperoxidase , edema , in vitro , adjuvant , lipopolysaccharide , oxadiazole , medicine , biochemistry , immunology , biology , organic chemistry , microbiology and biotechnology
1,3,4-oxadiazole ring is a versatile moiety with a wide range of pharmacological properties. The present work deals with the synthesis and evaluation of the anti-inflammatory activity of two novel 2,5-disubstituted-1,3,4-oxadiazoles (OSD and OPD).