Open AccessPopulation pharmacokinetics of bupivacaine in combined lumbar and sciatic nerve block
Author(s) -
Hanene Eljebari,
Nadia Jebabli,
Issam Salouage,
Emna Gaïes,
Mohamed Lakhal,
M. Boussofara,
Anis Klouz
Publication year - 2014
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.129318
Subject(s) - bupivacaine , pharmacokinetics , anesthesia , sciatic nerve , population , lumbar plexus , lumbar , medicine , volume of distribution , local anesthetic , surgery , pharmacology , environmental health
The primary aim of this study was to establish the population pharmacokinetic (PPK) model of bupivacaine after combined lumbar plexus and sciatic nerve blocks and secondary aim is to assess the effect of patient's characteristics including age, body weight and sex on pharmacokinetic parameters.