Open AccessMechanism of testicular protection of carvedilol in streptozotocin-induced diabetic rats
Author(s) -
Maggie M. Ramzy,
Azza A. K. El-Sheikh,
Maha Yehia Kamel,
Sayed F. Abdelwahab,
Mohamed A. Morsy
Publication year - 2014
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.129307
Subject(s) - carvedilol , streptozotocin , oxidative stress , malondialdehyde , diabetes mellitus , lipid peroxidation , glutathione , antioxidant , endocrinology , medicine , pharmacology , apoptosis , chemistry , biochemistry , heart failure , enzyme
Male sub-fertility and infertility are major complications of diabetes mellitus. The non-selective β-blocker carvedilol has been reported to have favorable effects on some of the diabetic complications based on its antioxidant and anti-apoptotic effects. This study aims to evaluate the possible testicular protective effect of carvedilol in streptozotocin (STZ)-induced diabetic rat model and its possible mechanisms.