Open AccessClopidogrel: A possible exacerbating factor for psoriasis
Author(s) -
Vikram K. Mahajan,
Gayatri Khatri,
Neel Prabha,
C. Abhinav,
Vikas Sharma
Publication year - 2014
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.125194
Subject(s) - clopidogrel , medicine , psoriasis , aspirin , palmoplantar pustulosis , coronary artery disease , atorvastatin , ticlopidine , dermatology , atenolol , comorbidity , cardiology , blood pressure
A 64-year-old man developed palmoplantar pustulosis eventuating into palmoplantar pustular psoriasis following treatment with diltiazem, atenolol, aspirin and atorvastatin for suspected coronary artery disease (CAD). Treatment for psoriasis, stopping atenolol and substituting aspirin with clopidogrel did not benefit. Subsequently, he stopped all his drugs and did not develop psoriasis or symptoms/signs of CAD. Re-challenge with oral clopidogrel precipitated his skin lesions. This case has implications for patients having psoriasis and cardiovascular comorbidity where clopidogrel/ticlopidine or aspirin may not be a useful alternative.