Open AccessLevofloxacin and furazolidone induced toxic epidermal necrosis
Author(s) -
Sushil Kumar Varma,
Shanta Das Sutradhar,
Arup Kumar Misra
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.121380
Subject(s) - furazolidone , levofloxacin , toxic epidermal necrolysis , medicine , drug , dermatology , pharmacology , antibiotics , microbiology and biotechnology , biology
Toxic epidermal necrolysis (TEN), also known as Lyell's syndrome, is a severe cutaneous drug reaction with a high mortality. Immune response is the possible cause in its pathogenesis. Levofloxacin is one of the most commonly used quinolones and has been reported to cause of TEN. On the other hand, furazolidone was proposed to augment the action of immediate hypersensitivity of levofloxacin by its cytotoxic effect and by the generation of free radicals. Here, we present a case of TEN where, levofloxacin and furazolidone were the probable cause of these adverse drug reactions.