Reversal of multidrug resistance by 5,5′-dimethoxylariciresinol-4-O-β-D-glucoside in doxorubicin-resistant human leukemia K562/DOX | Zendy

Tianxiao Wang | Zendy; Xiaoyan Shi | Zendy; Yue Cong | Zendy; Shiguang Wang | Zendy; Yingying Wang | Zendy; Zhong-qin Zhang | Zendy

Open Access

Reversal of multidrug resistance by 5,5′-dimethoxylariciresinol-4-O-β-D-glucoside in doxorubicin-resistant human leukemia K562/DOX

Author(s) -

Tianxiao Wang,

Xiaoyan Shi,

Yue Cong,

Shiguang Wang,

Yingying Wang,

Zhong-qin Zhang

Publication year - 2013

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.121371

Subject(s) - doxorubicin , rhodamine 123 , propidium iodide , multiple drug resistance , k562 cells , mtt assay , pharmacology , apoptosis , cytotoxicity , chemistry , microbiology and biotechnology , biology , biochemistry , medicine , chemotherapy , programmed cell death , in vitro , antibiotics

The objective of this study was to investigate the reversal effects of 5,5'-dimethoxylariciresinol-4'-O-β-D-glucoside (DMAG) extracted from traditional Chinese medicines Mahonia on multidrug resistance (MDR) of human leukemia cells to chemotherapeutic agents.

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