Open AccessReversal of multidrug resistance by 5,5′-dimethoxylariciresinol-4-O-β-D-glucoside in doxorubicin-resistant human leukemia K562/DOX
Author(s) -
Tianxiao Wang,
Xin Shi,
Cong Ye,
Shiguang Wang,
Yingying Wang,
Zhong-qin Zhang
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.121371
Subject(s) - doxorubicin , rhodamine 123 , propidium iodide , multiple drug resistance , pharmacology , k562 cells , mtt assay , chemistry , apoptosis , cytotoxicity , microbiology and biotechnology , biology , biochemistry , medicine , chemotherapy , programmed cell death , in vitro , antibiotics
The objective of this study was to investigate the reversal effects of 5,5'-dimethoxylariciresinol-4'-O-β-D-glucoside (DMAG) extracted from traditional Chinese medicines Mahonia on multidrug resistance (MDR) of human leukemia cells to chemotherapeutic agents.