Open AccessChemoprotective potential of Coccinia indica against cyclophosphamide-induced toxicity
Author(s) -
Ramesh K Nitharwal,
Hasit Patel,
Manvendra Singh Karchuli,
Rajesh R. Ugale
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.117783
Subject(s) - micronucleus test , genotoxicity , micronucleus , oxidative stress , malondialdehyde , pharmacology , alkaline phosphatase , glutathione , chemoprotective , chemistry , catalase , toxicity , traditional medicine , antioxidant , biology , biochemistry , enzyme , medicine , organic chemistry
Although cyclophosphamide (CP), an alkylating agent, is used in the treatment of cancer owing to its broad-spectrum efficacy, its metabolites exhibit severe undesired toxicities in normal cells. The present study was aimed to investigate the chemoprotective potential of Coccinia indica against CP-induced oxidative stress, genotoxicity, and hepatotoxicity.