Chemoprotective potential of Coccinia indica against cyclophosphamide-induced toxicity | Zendy

Rajesh R. Ugale | Zendy; RameshK Nitharwal | Zendy; Hasit Patel | Zendy; ManvendraSingh Karchuli | Zendy

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Chemoprotective potential of Coccinia indica against cyclophosphamide-induced toxicity

Author(s) -

Rajesh R. Ugale,

RameshK Nitharwal,

Hasit Patel,

ManvendraSingh Karchuli

Publication year - 2013

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.117783

Subject(s) - micronucleus test , genotoxicity , micronucleus , oxidative stress , malondialdehyde , pharmacology , alkaline phosphatase , glutathione , chemoprotective , chemistry , catalase , toxicity , traditional medicine , antioxidant , biology , biochemistry , enzyme , medicine , organic chemistry

Although cyclophosphamide (CP), an alkylating agent, is used in the treatment of cancer owing to its broad-spectrum efficacy, its metabolites exhibit severe undesired toxicities in normal cells. The present study was aimed to investigate the chemoprotective potential of Coccinia indica against CP-induced oxidative stress, genotoxicity, and hepatotoxicity.

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