Open AccessAn evaluation of the protective role of α-tocopherol on free radical induced hepatotoxicity and nephrotoxicity due to chromium in rats
Author(s) -
Rajendran Balakrishnan,
Chitturi Sree Venkat Satish Kumar,
Matukumalli Usha Rani,
Mylaram Kistaiah Srikanth,
G. Boobalan,
A Gopala Reddy
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.117778
Subject(s) - malondialdehyde , lipid peroxidation , chemistry , creatinine , superoxide dismutase , nephrotoxicity , antioxidant , alanine transaminase , hexavalent chromium , glutathione , aspartate transaminase , kidney , medicine , blood urea nitrogen , biochemistry , pharmacology , alkaline phosphatase , chromium , endocrinology , enzyme , organic chemistry
To avert the health problems induced by many environmental pollutants, available antioxidants have been evaluated. The present study was aimed to investigate whether α-tocopherol could protect the hexavalent chromium (Cr VI)-induced peroxidation in the liver and kidney and to explore the underlying mechanism of the same.