Open AccessEffect of sequential versus standard Helicobacter pylori eradication therapy on the associated iron deficiency anemia in children
Author(s) -
Hamid Habıb,
Hussam Murad,
Elamir Mahmoud Amir,
Taher F. Halawa
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.117757
Subject(s) - clarithromycin , tinidazole , medicine , amoxicillin , helicobacter pylori , gastroenterology , regimen , iron deficiency anemia , ferritin , gold standard (test) , urea breath test , breath test , anemia , antibiotics , helicobacter pylori infection , metronidazole , biology , microbiology and biotechnology
Helicobacter pylori infection may be associated with low iron stores and iron deficiency anemia. Eradication of infection by the standard 10-day therapy (a proton pump inhibitor [PPI], clarithromycin and amoxicillin; each given orally, twice daily) is decreasing. The sequential 10-day therapy (a PPI and amoxicillin; each given orally twice daily for 5 days; followed by a PPI, clarithromycin and tinidazole; each given orally twice daily for another 5 days) may achieve higher eradication rates. This study was designed to investigate, which eradication regimen; sequential or standard; more effectively improves the associated iron status and iron deficiency in children.