Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction | Zendy

NithyaJ Gogtay | Zendy; ShaunakP Kulkarni | Zendy; SanjanaR Shah | Zendy; PrashantP Kadam | Zendy; Kannan Sridharan | Zendy; NivruttiK Hase | Zendy; ParthaP Shetty | Zendy; UrmilaM Thatte | Zendy

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Pharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction

Author(s) -

NithyaJ Gogtay,

ShaunakP Kulkarni,

SanjanaR Shah,

PrashantP Kadam,

Kannan Sridharan,

NivruttiK Hase,

ParthaP Shetty,

UrmilaM Thatte

Publication year - 2013

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.114997

Subject(s) - primaquine , pharmacokinetics , medicine , renal function , kidney disease , dialysis , pharmacology , gastroenterology , urology , immunology , malaria , chloroquine

The pharmacokinetics of primaquine has not been studied in special populations. Being a basic compound, preferential binding to alpha-1 acid glycoprotein and substrate for P-glycoprotein, may predispose the drug for an altered pharmacokinetics in states of renal dysfunction. This study attempts to evaluate the pharmacokinetics of a single oral dose (15 mg) of primaquine in severely impaired renal function and end stage renal dysfunction patients compared to healthy participants.

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