Open AccessPharmacokinetics of single-dose primaquine in patients with chronic kidney dysfunction
Author(s) -
Shrirang Vasant Kulkarni,
Sanjana R Shah,
Prashant P Kadam,
Kannan Sridharan,
N K Hase,
Partha Shetty,
Urmila M Thatte,
Nithya J Gogtay
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.114997
Subject(s) - primaquine , pharmacokinetics , medicine , renal function , kidney disease , dialysis , pharmacology , gastroenterology , urology , immunology , malaria , chloroquine
The pharmacokinetics of primaquine has not been studied in special populations. Being a basic compound, preferential binding to alpha-1 acid glycoprotein and substrate for P-glycoprotein, may predispose the drug for an altered pharmacokinetics in states of renal dysfunction. This study attempts to evaluate the pharmacokinetics of a single oral dose (15 mg) of primaquine in severely impaired renal function and end stage renal dysfunction patients compared to healthy participants.