Open AccessOral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats
Author(s) -
Amir Abbas Farshid,
Esmaeal Tamaddonfard,
Sepideh Ranjbar
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.108283
Subject(s) - histidine , vitamin c , malondialdehyde , saline , antioxidant , chemistry , pharmacology , vitamin e , vitamin , oxidative stress , medicine , endocrinology , biochemistry , enzyme
Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) administration of vitamin C and histidine on the CP-induced HC in rats.