Oral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats | Zendy

Amir-Abbas Farshid | Zendy; Esmaeal Tamaddonfard | Zendy; Sepideh Ranjbar | Zendy

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Oral administration of vitamin C and histidine attenuate cyclophosphamide-induced hemorrhagic cystitis in rats

Author(s) -

Amir-Abbas Farshid,

Esmaeal Tamaddonfard,

Sepideh Ranjbar

Publication year - 2013

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.108283

Subject(s) - vitamin c , histidine , malondialdehyde , saline , pharmacology , antioxidant , chemistry , vitamin e , vitamin , medicine , oxidative stress , endocrinology , biochemistry , enzyme

Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) administration of vitamin C and histidine on the CP-induced HC in rats.

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