Open AccessEffect of combination of aripiprazole with carbamazepine and fluvoxamine on liver functions in experimental animals
Author(s) -
C. S. Shastry,
Aboobakar A Shafeeque,
Badavanahalli J Ashwathnarayana
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.108280
Subject(s) - aripiprazole , fluvoxamine , pharmacology , carbamazepine , cyp3a4 , medicine , liver function , atypical antipsychotic , endocrinology , antipsychotic , schizophrenia (object oriented programming) , cytochrome p450 , serotonin , epilepsy , fluoxetine , metabolism , receptor , psychiatry
Aripiprazole, a new atypical antipsychotic drug extensively metabolized by enzyme CYP3A4, is found to produce asymptomatic elevation of serum transaminase levels on long-term treatment. The present study aims to evaluate the hepatotoxic effect of aripiprazole when coprescribed with carbamazepine and fluvoxamine.