Effect of combination of aripiprazole with carbamazepine and fluvoxamine on liver functions in experimental animals | Zendy

C. S. Shastry | Zendy; AboobakarA Shafeeque | Zendy; BadavanahalliJ Ashwathnarayana | Zendy

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Effect of combination of aripiprazole with carbamazepine and fluvoxamine on liver functions in experimental animals

Author(s) -

C. S. Shastry,

AboobakarA Shafeeque,

BadavanahalliJ Ashwathnarayana

Publication year - 2013

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.108280

Subject(s) - aripiprazole , fluvoxamine , pharmacology , carbamazepine , cyp3a4 , medicine , liver function , atypical antipsychotic , endocrinology , antipsychotic , schizophrenia (object oriented programming) , cytochrome p450 , serotonin , epilepsy , fluoxetine , metabolism , receptor , psychiatry

Aripiprazole, a new atypical antipsychotic drug extensively metabolized by enzyme CYP3A4, is found to produce asymptomatic elevation of serum transaminase levels on long-term treatment. The present study aims to evaluate the hepatotoxic effect of aripiprazole when coprescribed with carbamazepine and fluvoxamine.

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