Open AccessZotepine-induced convulsive seizures in a chronic case of treatment resistant paranoid schizophrenia
Author(s) -
Praveen Khairkar,
Neha Gupta,
Sushil Kumar Varma
Publication year - 2013
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.106447
Subject(s) - adverse effect , dose , medicine , seizure threshold , epilepsy , schizophrenia (object oriented programming) , paranoid schizophrenia , anesthesia , pediatrics , psychology , psychosis , psychiatry , pharmacology , anticonvulsant
Adverse effects to antipsychotics are varied, frequently intolerable, often serious and sometimes fatal in clinical practice. Seizures are one of these adverse effects. Almost all first and second generation antipsychotics elicit dose-dependent lowering of seizure threshold, indicating increased seizure risk at higher drug dosages. The adverse event of zotepine induced seizure is published in few case reports. We report the occurrence of myoclonic seizure progressing to generalized tonic-clonic seizures with zotepine along with clear temporal association of dose dependent modulation evident in this case.