Open AccessProtective effect of methanolic extract of Garcinia indica fruits in 6-OHDA rat model of Parkinson′s disease
Author(s) -
Bhaveshkumar V Antala,
Manishkumar S. Patel,
Satish V Bhuva,
Shiv Shankar Gupta,
Samir Rabadiya,
Mangala Lahkar
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.103242
Subject(s) - neuroprotection , apomorphine , substantia nigra , analysis of variance , parkinson's disease , striatum , dopaminergic , medicine , context (archaeology) , chemistry , traditional medicine , pharmacology , dopamine , biology , disease , paleontology
Several studies have reported that antioxidants play an important role in Parkinson's disease (PD). Garcinia indica extract is a natural antioxidant, the present study was undertaken to evaluate the neuroprotective effect of methanolic extract of Garcinia indica (GIM) against 6-hydroxydopamine (6-OHDA) neurotoxicity for striatal dopaminergic neurons in the rat.