Protective effect of methanolic extract of Garcinia indica fruits in 6-OHDA rat model of Parkinson′s disease | Zendy

BhaveshkumarV Antala | Zendy; Mahesh J. Patel | Zendy; S. Bhuva | Zendy; S. K. Gupta | Zendy; Samir Rabadiya | Zendy; Mangala Lahkar | Zendy

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Protective effect of methanolic extract of Garcinia indica fruits in 6-OHDA rat model of Parkinson′s disease

Author(s) -

BhaveshkumarV Antala,

Mahesh J. Patel,

S. Bhuva,

S. K. Gupta,

Samir Rabadiya,

Mangala Lahkar

Publication year - 2012

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.103242

Subject(s) - neuroprotection , apomorphine , analysis of variance , parkinson's disease , dopaminergic , substantia nigra , striatum , medicine , pharmacology , traditional medicine , behavioural despair test , chemistry , dopamine , disease , hippocampus , antidepressant

Several studies have reported that antioxidants play an important role in Parkinson's disease (PD). Garcinia indica extract is a natural antioxidant, the present study was undertaken to evaluate the neuroprotective effect of methanolic extract of Garcinia indica (GIM) against 6-hydroxydopamine (6-OHDA) neurotoxicity for striatal dopaminergic neurons in the rat.

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