Open AccessEffects of pravastatin on the pharmacokinetic parameters of nimodipine after oral and intravenous administration in rats: Possible role of CYP3A4 inhibition by pravastatin
Author(s) -
Chong-Ki Lee,
JunShik Choi,
DongHyun Choi
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.100395
Subject(s) - nimodipine , pravastatin , bioavailability , pharmacology , pharmacokinetics , chemistry , cyp3a4 , oral administration , medicine , metabolism , cholesterol , cytochrome p450 , biochemistry , calcium , organic chemistry
The aim of this study was to investigate the effects of pravastatin on the pharmacokinetics of nimodipine in rats.