Open AccessAntidiarrheal efficacy of a quinazolin CFTR inhibitor on human intestinal epithelial cell and in mouse model of cholera
Author(s) -
Varanuj Chatsudthipong,
Jenvit Patanayindee,
Chatchai Muanprasat,
Sunhapas Soodvilai
Publication year - 2012
Publication title -
indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.100392
Subject(s) - cholera , pharmacology , chemistry , medicine , virology
This study aimed to evaluate the antidiarrheal efficacy and pharmacological properties of ethyl 2-(4-oxo-3-o-tolyl-3,4-dihydroquinazolin-2-ylthio)acetate (DQA) as an inhibitor of cystic fibrosis transmembrane conductance regulator protein (CFTR) both in vitro and in vivo.
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