Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT3receptor antagonist: An investigation in behaviour-based rodent models of depression | Zendy

Radhakrishnan Mahesh | Zendy; Baldev Kumar | Zendy; Ankur Jindal | Zendy; Shvetank Bhatt | Zendy; Thangaraj Devadoss | Zendy; Dilip Pandey | Zendy

Open Access

Antidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT₃receptor antagonist: An investigation in behaviour-based rodent models of depression

Author(s) -

Radhakrishnan Mahesh,

Baldev Kumar,

Ankur Jindal,

Shvetank Bhatt,

Thangaraj Devadoss,

Dilip Pandey

Publication year - 2012

Publication title -

indian journal of pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.286

H-Index - 59

eISSN - 1998-3751

pISSN - 0253-7613

DOI - 10.4103/0253-7613.100371

Subject(s) - behavioural despair test , tail suspension test , open field , antidepressant , reserpine , antagonist , analysis of variance , pharmacology , receptor antagonist , medicine , rodent , chemistry , endocrinology , psychology , receptor , biology , hippocampus , ecology

The present study was designed to investigate the antidepressant potential of (4-phenylpiperazin-1-yl) (quinoxalin-3-yl) methanone (4a), a novel 5-HT(3) receptor antagonist, with an optimal log P (2.84) and pA(2) value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depression.

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