Open AccessAntidepressant-like activity of (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a), a novel 5-HT3receptor antagonist: An investigation in behaviour-based rodent models of depression
Author(s) -
Radhakrishnan Mahesh,
B. K. Pavan Kumar,
Ankur Jindal,
Shvetank Bhatt,
Thangaraj Devadoss,
Dilip K. Pandey
Publication year - 2012
Publication title -
indian journal of pharmacology/the indian journal of pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.286
H-Index - 59
eISSN - 1998-3751
pISSN - 0253-7613
DOI - 10.4103/0253-7613.100371
Subject(s) - behavioural despair test , tail suspension test , open field , antidepressant , reserpine , antagonist , analysis of variance , pharmacology , receptor antagonist , medicine , rodent , chemistry , endocrinology , psychology , receptor , biology , hippocampus , ecology
The present study was designed to investigate the antidepressant potential of (4-phenylpiperazin-1-yl) (quinoxalin-3-yl) methanone (4a), a novel 5-HT(3) receptor antagonist, with an optimal log P (2.84) and pA(2) value (7.3) greater than ondansetron (6.9) using rodent behavioural models of depression.