Open AccessChlorpromazine as Prophylaxis for Bipolar Disorder with Treatment- and Electroconvulsive Therapy-Refractory Mania: Old Horse, New Trick
Author(s) -
Tamonud Modak,
Saurabh Kumar,
Arghya Pal,
Rishab Gupta,
Raman Deep Pattanayak,
Shubham Khandelwal
Publication year - 2017
Publication title -
indian journal of psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 24
eISSN - 0975-1564
pISSN - 0253-7176
DOI - 10.4103/0253-7176.211759
Subject(s) - mania , electroconvulsive therapy , olanzapine , mood stabilizer , haloperidol , bipolar disorder , chlorpromazine , refractory (planetary science) , psychology , psychiatry , mood , lithium (medication) , schizophrenia (object oriented programming) , medicine , anesthesia , dopamine , physics , astrobiology
A 22-year-old male diagnosed with bipolar affective disorder presented to us with a 3 rd episode mania resistant to both olanzapine and haloperidol as well as electroconvulsive therapy. He, however, responded to chlorpromazine (CPZ) which was also effective as a mood stabilizer. The patient had a relapse of his illness when CPZ was stopped and responded again when it was started. The case demonstrates that CPZ may have a role in as both an anti-manic agent and for the maintenance for bipolar disorders. The possible underlying mechanism for this role is also discussed.