Open AccessLong Loop Reflex 2 in Patients with Cortical Dementias: A Pilot Study
Author(s) -
Sadanandavalli Retnaswami Chandra,
Thomas Gregor Isaac,
Mahesh Mane,
Srikala Bharath,
B C Nagaraju
Publication year - 2017
Publication title -
indian journal of psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 24
eISSN - 0975-1564
pISSN - 0253-7176
DOI - 10.4103/0253-7176.203126
Subject(s) - dementia , frontotemporal dementia , disease , neuroscience , biomarker , reflex , latency (audio) , medicine , physical medicine and rehabilitation , psychology , audiology , pediatrics , psychiatry , biology , computer science , telecommunications , biochemistry
Dementia is a major public health problem and it appears to be a global epidemic. The prevalence is doubling every 5 years and it is expected that 70% of persons above 60 years will live in developing countries by 2020 and 15% of them are likely to suffer from dementia. Disease modifying treatments work only if initiated very early; however, diagnostic tools are not always able to clearly differentiate the different types in very early stage. Therefore, inexpensive and easily available biomarkers are needed to know if collectively they will improve the sensitivity of specific diagnosis. Therefore, in this pilot study, we have tried to analyze if long loop reflex (LLR2) is differentially affected in these two conditions early in the course of Alzheimer's dementia (AD) and frontotemporal dementia (FTD) based on hypothesis taking into account the anatomical substrates involved.