Open AccessLinezolid-Induced Near-Fatal Serotonin Syndrome During Escitalopram Therapy: Case Report and Review of Literature
Author(s) -
Ranganath R. Kulkarni,
Pratibha R. Kulkarni
Publication year - 2013
Publication title -
indian journal of psychological medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 24
eISSN - 0975-1564
pISSN - 0253-7176
DOI - 10.4103/0253-7176.122245
Subject(s) - serotonin syndrome , escitalopram , serotonergic , linezolid , monoamine oxidase , medicine , tyramine , pharmacology , adverse effect , serotonin , psychiatry , chemistry , antidepressant , biology , anxiety , receptor , enzyme , staphylococcus aureus , biochemistry , genetics , vancomycin , bacteria
Linezolid is a synthetic antimicrobial agent of the oxazolidinone class with weak, nonspecific inhibitor of monoamine oxidase enzymes. Concomitant therapy with an adrenergic or serotonergic agent or consuming tyramine (>100 mg/day) may induce serotonin syndrome (SS). We present a case report of near-fatal adverse interaction between linezolid and escitalopram inducing SS in a 65-year-old woman with sepsis, under empirical antibiotic treatment. This report also summarizes the current relevant literature as identified via PubMed, EMBASE, and PsycINFO, supplemented with a manual search of cross references.