Open AccessPhysicochemical and pharmacokinetic parameters in drug selection and loading for transdermal drug delivery
Author(s) -
N. S. Chandrashekar,
RH Shobha Rani
Publication year - 2008
Publication title -
indian journal of pharmaceutical sciences/indian journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 57
eISSN - 1998-3743
pISSN - 0250-474X
DOI - 10.4103/0250-474x.40340
Subject(s) - transdermal , pharmacokinetics , drug , pharmacology , drug delivery , medicine , selection (genetic algorithm) , transdermal patch , chemistry , computer science , organic chemistry , artificial intelligence
Skin of an average adult body covers a surface of approximately 2 m2 and receives about one-third of the blood circulating through the body. The transdermal route of administration cannot be employed for a large number of drugs. The rationality of drug selection based on pharmacokinetic parameters and physicochemical properties of the drug are the important factors to be considered for deciding its suitability of drug for delivery by transdermal route.