Open Access<i>In vitro</i> antiviral activity of some novel isatin derivatives against HCV and SARS-CoV viruses
Author(s) -
Periyasamy Selvam,
N Murgesh,
M. Chandramohan,
Erik De Clercq,
Els Keyaerts,
Leen Vijgen,
Piet Maes,
Johan Neyts,
M. Van Ranst
Publication year - 2008
Publication title -
indian journal of pharmaceutical sciences/indian journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 57
eISSN - 1998-3743
pISSN - 0250-474X
DOI - 10.4103/0250-474x.40339
Subject(s) - vero cell , virology , in vitro , isatin , hepatitis c virus , chemistry , virus , cytopathic effect , biology , biochemistry , organic chemistry
4-[(1,2-dihydro-2-oxo-3H-indol-3-ylidene)amino]-N(4,6-dimethyl-2-pyrimidiny)benzene sulphonamide and its derivatives were evaluated for antiviral activity against Pathogenic viruses such as Hepatitis C Virus and SARS-CoV in Vero and Huh 5-2 cells, respectively. The 5-fluoro derivative inhibited the HCV RNA synthesis at 6 mug/ml, without toxicity at a concentration up to 42 mug/ml in Huh 5-2 cells. Among the compounds tested SPIII-5F exhibits the 45% maximum protection against replication of SARS-CoV in Vero cells.