Open AccessFormulation and characterization of mucoadhesive buccal films of glipizide
Author(s) -
Mona Semalty,
Ajay Semalty,
Ganesh Kumar
Publication year - 2008
Publication title -
indian journal of pharmaceutical sciences/indian journal of pharmaceutical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.245
H-Index - 57
eISSN - 1998-3743
pISSN - 0250-474X
DOI - 10.4103/0250-474x.40330
Subject(s) - glipizide , swelling , buccal administration , folding endurance , chemistry , permeation , sodium carboxymethylcellulose , chromatography , nuclear chemistry , materials science , sodium , membrane , pharmacology , polymer , composite material , organic chemistry , biochemistry , medicine , ethyl cellulose , diabetes mellitus , endocrinology
Mucoadhesive buccal films of glipizide were prepared by solvent casting technique using hydroxypropylmethylcellulose, sodium carboxymethylcellulose, carbopol-934P and Eudragit RL-100. Prepared films were evaluated for weight, thickness, surface pH, swelling index, in vitro residence time, folding endurance, in vitro release, permeation studies and drug content uniformity. The films exhibited controlled release over more than 6 h. From the study it was concluded that the films containing 5 mg glipizide in 4.9% w/v hydroxypropylmethylcellulose and 1.5% w/v sodium carboxymethylcellulose exhibited satisfactory swelling, an optimum residence time and promising drug release. The formulation was found to be suitable candidate for the development of buccal films for therapeutic use.