Open AccessAndrogen insensitivity syndrome: Risk of malignancy and timing of surgery in a paediatric and adolescent population
Author(s) -
Dragan Kravarušić,
Emmanuelle Séguier-Lipszyc,
Elad Feigin,
Revital Nimri,
Nessia Nagelberg,
Enrique Freud
Publication year - 2011
Publication title -
african journal of paediatric surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.163
H-Index - 17
eISSN - 0189-6725
pISSN - 0974-5998
DOI - 10.4103/0189-6725.86061
Subject(s) - medicine , gonadoblastoma , malignancy , androgen insensitivity syndrome , population , gynecology , pediatrics , general surgery , pathology , cancer , karyotype , prostate cancer , biochemistry , chemistry , androgen receptor , environmental health , chromosome , gene
Management of female phenotype XY disorders poses a series of problems for the treating clinician. Even after a series of investigations and imaging modalities, there are lingering doubts about the exact nature of the disease and the correct management option. Optimal timing and necessity for removal of their testes have been a debated issue by physicians. There is a generally accepted opinion among physicians that the risk of malignancy in androgen insensitivity syndrome (AIS) is considerably lower than with other intersex disorders and occurs at a later age.