Open AccessMixed gonadal dysgenesis in Yaoundé: A preliminary experience about three cases
Author(s) -
FF Mouafo Tambo,
Sophie Dahoun,
Cyril Kamadjou,
AS Nwaha Makon,
G Fossi,
OG Andze,
MA Sosso,
Pierre-Yves Mure
Publication year - 2016
Publication title -
african journal of paediatric surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.163
H-Index - 17
eISSN - 0189-6725
pISSN - 0974-5998
DOI - 10.4103/0189-6725.187822
Subject(s) - medicine , gonadal dysgenesis , karyotype , gonad , incidence (geometry) , gynecology , turner syndrome , abnormality , epidemiology , pediatrics , gonadoblastoma , chromosome , genetics , biology , physics , psychiatry , optics , gene
Mixed gonadal dysgenesis is characterised by unilateral chromosomal abnormality, which is probably the result of anaphase lag during mitosis. The 45, XO/46, XY karyotype is the most common form of mosaicism involving the Y chromosome. It is a rare clinical entity with a worldwide incidence of 1.5/10,000 live births. Its epidemiology in Sub-Saharan Africa is not known. This study reports experience in the management of 3 cases at the Yaounde Gynecologic-Obstetric and Paediatric Hospital. From November 2009 to November 2014, 3 cases were successfully managed at our institution.