Open AccessVan der Woude syndrome: A review of 11 cases seen at the Lagos University Teaching Hospital
Author(s) -
Olutayo James,
WL Adeyemo,
Christian Ibezi Emeka,
M.O. Ogunlewe,
Akinola Ladipo Ladeinde,
Azeez Butali
Publication year - 2014
Publication title -
african journal of paediatric surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.163
H-Index - 17
eISSN - 0189-6725
pISSN - 0974-5998
DOI - 10.4103/0189-6725.129235
Subject(s) - medicine , general surgery , pediatrics , family medicine
Van der Woude syndrome (VWS), an autosomal dominant condition associated with clefts of the lip and/or palate and lower lip pits and is caused by mutations in interferon regulatory factor six gene. It is reported to be the most common syndromic cleft world-wide. Non-penetrance for the lip pit phenotype is found in at least 10% of affected individuals and those without the pits are phenocopies for non-syndromic clefting. The aim of this study is to present the phenotypic characteristic of VWS seen at the Lagos University Teaching Hospital (LUTH) cleft clinic.