Open AccessAssessment of the antidiabetic potential of Cassia grandis using an in vivo model
Author(s) -
Sandesh Lodha,
Shrikant V. Joshi,
Bhavin Vyas,
Mohini Upadhye,
Megha S Kirve,
Shweta S Salunke,
Sheetal K Kadu,
Manasi V Rogye
Publication year - 2010
Publication title -
agricultural policy paper
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
ISSN - 0110-5558
DOI - 10.4103/0110-5558.72429
Subject(s) - alloxan , glibenclamide , cassia , diabetes mellitus , in vivo , chemistry , traditional medicine , body weight , cholesterol , medicine , pharmacology , endocrinology , biology , microbiology and biotechnology , alternative medicine , traditional chinese medicine , pathology
The aqueous and ethanolic extracts of C. grandis (Family: Leguminosae) were evaluated for antidiabetic activity by a glucose tolerance test, in normal rats and alloxan-induced diabetic rats. The aqueous and ethanolic extracts showed that they significantly lowered the blood glucose levels to normal in the glucose tolerance test. In alloxan-induced diabetic rats the maximum reduction in blood glucose was observed after three hours, at a dose level of 150 mg/kg of body weight. The percentage of protection given by the aqueous and ethanolic extracts was 32.72 and 46.42%, respectively. In the long-term treatment of alloxan-induced diabetic rats, the degree of protection was determined by measuring the blood glucose, cholesterol, and triglycerides on the tenth day. Both the extracts showed a significant antidiabetic activity comparable to that of glibenclamide. These results showed that the Cassia grandis possessed significant antidiabetic activity.