Open AccessSynthesis, characterization, and analgesic activity of novel schiff base of isatin derivatives
Author(s) -
Rajaram Prakash Chinnasamy,
Raja Sundararajan,
Saravanan Govindaraj
Publication year - 2010
Publication title -
agricultural policy paper
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.325
H-Index - 33
ISSN - 0110-5558
DOI - 10.4103/0110-5558.72428
Subject(s) - isatin , chemistry , elemental analysis , analgesic , pentazocine , schiff base , nuclear chemistry , analgesic agents , indoline , organic chemistry , medicinal chemistry , stereochemistry , pharmacology , medicine
In the present study, a series of novel Schiff bases of isatin [5a-5l] were synthesized by condensation of imesatin with different aromatic aldehydes. The imesatins were synthesized by the reaction of isatin with p-phenylenediamine. The chemical structures of the synthesized compounds were confirmed by means of Infrared (IR), Mass spectroscopy, and Elemental analysis. These compounds were screened for the analgesic activity by the tail-immersion method at a dose of 200 mg/kg body weight. Among the tested compounds 3-(4-(4-hydroxy-3-methoxylbenzylideneamino) phenylimino) indoline-2-one (5i) exhibited better analgesic activity when compared to standard pentazocine. From the above-mentioned results it may be concluded that compounds containing electron-donating groups exhibit better analgesic activity than the electron-withdrawing groups.