Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population | Zendy

HK Bid | Zendy; Rituraj Konwar | Zendy; Madhukar Saxena | Zendy; P. Chaudhari | Zendy; CG Agrawal | Zendy; Monisha Banerjee | Zendy

Open Access

Association of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population

Author(s) -

HK Bid,

Rituraj Konwar,

Madhukar Saxena,

P. Chaudhari,

CG Agrawal,

Monisha Banerjee

Publication year - 2010

Publication title -

journal of postgraduate medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.405

H-Index - 52

eISSN - 0972-2823

pISSN - 0022-3859

DOI - 10.4103/0022-3859.68633

Subject(s) - gstp1 , type 2 diabetes mellitus , genotype , biology , glutathione s transferase , oxidative stress , population , multiplex polymerase chain reaction , genetics , gene , glutathione , diabetes mellitus , medicine , polymerase chain reaction , endocrinology , enzyme , biochemistry , environmental health

Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense. The oxidative stress becomes evident as a result of accumulation of ROS in conditions of inflammation and Type 2 diabetes mellitus (T2DM). The genes involved in redox balance, which determines the susceptibility to T2DM remain unclear. In humans, the glutathione S-transferase (GST) family comprises several classes of GST isozymes, the polymorphic variants of GSTM1, T1 and P1 genes result in decreased or loss of enzyme activity.

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