Open AccessAssociation of glutathione S-transferase (GSTM1, T1 and P1) gene polymorphisms with type 2 diabetes mellitus in north Indian population
Author(s) -
Hemant K. Bid,
Rituraj Konwar,
M. C. Saxena,
Paresh Chaudhari,
CG Agrawal,
Monisha Banerjee
Publication year - 2010
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/0022-3859.68633
Subject(s) - gstp1 , type 2 diabetes mellitus , medicine , glutathione s transferase , genotype , population , oxidative stress , diabetes mellitus , glutathione , genetics , gene , endocrinology , biology , enzyme , biochemistry , environmental health
Diabetes mellitus is associated with an increased production of reactive oxygen species (ROS) and a reduction in antioxidant defense. The oxidative stress becomes evident as a result of accumulation of ROS in conditions of inflammation and Type 2 diabetes mellitus (T2DM). The genes involved in redox balance, which determines the susceptibility to T2DM remain unclear. In humans, the glutathione S-transferase (GST) family comprises several classes of GST isozymes, the polymorphic variants of GSTM1, T1 and P1 genes result in decreased or loss of enzyme activity.