Open AccessTargeting connexin 43 in diabetic wound healing: Future perspectives
Author(s) -
Surabhi Bajpai,
Vijay K. Shukla,
Kamlakar Tripathi,
Saripella Srikrishna,
Rajesh Kumar Singh
Publication year - 2009
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/0022-3859.48786
Subject(s) - medicine , connexin , diabetes mellitus , wound healing , etiology , disease , intensive care medicine , bioinformatics , surgery , pathology , gap junction , endocrinology , intracellular , biology , microbiology and biotechnology
The unknown mechanisms of impaired tissue repair in diabetes mellitus are making this disease a serious clinical problem for the physicians worldwide. The lacuna in the knowledge of the etiology of diabetic wounds necessitates more focused research in order to develop new targeting tools with higher efficacy for their effective management. Gap-junction proteins, connexins, have shown some promising results in the process of diabetic wound healing. Till now the role of connexins has been implicated in peripheral neuropathy, deafness, skin disorders, cataract, germ cell development and treatment of cancer. Recent findings have revealed that gap junctions play a key role in normal as well as diabetic wound healing. The purpose of this review is to provide the information related to etiology, epidemiology, clinical presentation of diabetic wounds and to analyze the role of connexin 43 (Cx43) in the diabetic wound healing process. The current control strategies and the future research challenges have also been discussed briefly in this review.