Open AccessErythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)
Author(s) -
Anurag Gupta,
G. Kesava Reddy,
Manu Goyal,
M R Kasaragadda
Publication year - 2017
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/0022-3859.201413
Subject(s) - medicine , cd34 , cd117 , bone marrow , karyotype , leukemia , chemotherapy , pathology , bone marrow aspirate , immunology , stem cell , gene , chromosome , genetics , biology
Erythrophagocytosis by leukemic blasts is a rare phenomenon. We report a case of a female diagnosed with acute monoblastic leukemia with leukemic blasts that were CD34 and CD117 negative, showing erythrophagocytosis, vacoulations, and a rare t(8;16) on bone marrow karyotype which is associated with a poor prognosis despite intensive chemotherapy. Meticulous bone marrow examination in such a scenario may point towards the presence of t(8;16) and help clinicians take a well-informed clinical decision.