Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16) | Zendy

Anurag Gupta | Zendy; G. Abhinav Kumar Reddy | Zendy; Manu Goyal | Zendy; MR Kasaragadda | Zendy

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Erythrophagocytosis by blasts in a case of de novo acute monoblastic leukemia with rare but characteristic t(8;16)

Author(s) -

Anurag Gupta,

G. Abhinav Kumar Reddy,

Manu Goyal,

MR Kasaragadda

Publication year - 2017

Publication title -

journal of postgraduate medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.405

H-Index - 52

eISSN - 0972-2823

pISSN - 0022-3859

DOI - 10.4103/0022-3859.201413

Subject(s) - medicine , cd34 , cd117 , bone marrow , karyotype , leukemia , chemotherapy , pathology , bone marrow aspirate , immunology , stem cell , gene , chromosome , genetics , biology

Erythrophagocytosis by leukemic blasts is a rare phenomenon. We report a case of a female diagnosed with acute monoblastic leukemia with leukemic blasts that were CD34 and CD117 negative, showing erythrophagocytosis, vacoulations, and a rare t(8;16) on bone marrow karyotype which is associated with a poor prognosis despite intensive chemotherapy. Meticulous bone marrow examination in such a scenario may point towards the presence of t(8;16) and help clinicians take a well-informed clinical decision.

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