Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection | Zendy

Sreejesh Sreedharanunni | Zendy; MUS Sachdeva | Zendy; Gaurav Prakash | Zendy; Reena Das | Zendy

Open Access

Persistent γδ T large granular lymphocytosis in a patient with refractory pure red cell aplasia, celiac disease, and chronic hepatitis B infection

Author(s) -

Sreejesh Sreedharanunni,

MUS Sachdeva,

Gaurav Prakash,

Reena Das

Publication year - 2015

Publication title -

journal of postgraduate medicine

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.405

H-Index - 52

eISSN - 0972-2823

pISSN - 0022-3859

DOI - 10.4103/0022-3859.168739

Subject(s) - medicine , lymphocytosis , immunology , cytotoxic t cell , pure red cell aplasia , disease , hepatitis , pathology , bone marrow , biochemistry , chemistry , in vitro

The disorders of large granular lymphocytes include reactive proliferation as well as indolent or aggressive neoplasms of cytotoxic T cells, γδ T cells, and natural killer (NK) cells. They are associated with autoimmune and infectious disorders and have varied immunophenotypic features. We report a case, which highlights this complex association of autoimmune and infectious diseases with large granular lymphocytosis, the overlapping spectrum of large granular lymphocyte leukemias, and γδ T cell lymphomas as well as the difficulties in the diagnosis and management of these indolent T cell lymphomas in the usual clinical settings.

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