Open AccessPOEMS syndrome associated with plasmacytoma of the clivus: "Time discovers the truth"
Author(s) -
Jayakar Thomas,
Boby Varkey Maramattom,
Jophy Varghese,
Presoon Kuruvilla
Publication year - 2016
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/0022-3859.166181
Subject(s) - poems syndrome , medicine , organomegaly , polyneuropathy , pathology , papilledema , plasmacytoma , plasma cell , multiple myeloma , castleman disease , disease , radiology , bone marrow
Polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes (POEMS) syndrome is characterized by the presence of a monoclonal plasma cell disorder, peripheral neuropathy, and one or more of the following features: Osteosclerotic myeloma, Castleman's disease (angiofollicular lymph node hyperplasia), increased levels of serum vascular endothelial growth factor (VEGF), organomegaly, endocrinopathy, edema, typical skin changes, and papilledema. [1] Solitary plasmacytomas most frequently occur in the bone but can also be found in soft tissues (extramedullary plasmacytoma). [2] We report a case that showed a rare association of POEMS syndrome with a plasmacytoma of the clivus.