Open AccessCorrelation of renin angiotensin system (RAS) candidate gene polymorphisms with response to Ramipril in patients with essential hypertension
Author(s) -
Sumeet Gupta,
I Chattopadhyaya,
Bal K. Agrawal,
Prabodh K. Sehajpal,
Rajesh Kumar Goel
Publication year - 2015
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/0022-3859.147028
Subject(s) - ramipril , medicine , blood pressure , angiotensin converting enzyme , essential hypertension , renin–angiotensin system , endocrinology , genotype , pharmacology , ace inhibitor , genotyping , gastroenterology , gene , genetics , biology
The renin-angiotensin system (RAS) is an important facet of blood pressure regulation physiology. Treatment of essential hypertension targets the RAS using Angiotensin Converting Enzyme Inhibitors (ACEIs). However, ACEIs are not uniformly effective and show inter-individual pharmacodynamic variations.