Open AccessDoes follistatin gene have any direct role in the manifestation of polycystic ovary syndrome in Indian women?
Author(s) -
Shilpi Dasgupta,
S V S Pisapati,
K Neelaveni,
A Kathragadda,
Sudhakar Godi,
M B Reddy
Publication year - 2012
Publication title -
journal of postgraduate medicine/journal of postgraduate medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.405
H-Index - 52
eISSN - 0972-2823
pISSN - 0022-3859
DOI - 10.4103/0022-3859.101386
Subject(s) - polycystic ovary , medicine , follistatin , exon , genetics , gene , candidate gene , allele , endocrinology , biology , obesity , insulin resistance
Out of a panel of 37 candidate genes tested for linkage with polycystic ovary syndrome (PCOS), the strongest evidence of linkage was reported in the follistatin (FST) gene region. Subsequently, a couple of studies outside India investigated the FST gene for the presence of any mutations and its association with PCOS and the results were found to be largely inconsistent probably due to differences in the ethnic backgrounds and small sample sizes.